Rent Office 345 Park Avenue South

Rent Office - 345 Park Avenue South

$ / SF SF Monthly Rent
$ / SF SF Monthly Rent

Rent Sublease Office - 345 Park Avenue South

$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
Rent Coworking Office
Type of Space Class A Class B Class C
Windowed office/person $ 2,000/mo $ 1,250/mo $ 750/mo
Interior office/person $ 1,250/mo $ 750/mo $ 500/mo

Nearby office Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street $ 80 7,100 $ 47,496
Madison Ave & East 25th Street $ 89 4,800 $ 35,600
Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street $ 80 82,800 $ 553,897
Madison Ave & East 25th Street $ 85 13,400 $ 94,916
Madison Ave & East 28th Street $ 72 38,900 $ 232,508
Madison Ave & Between East 23rd Street $ 124 28,600 $ 294,341
Address $ / SF SF Monthly Rent
Union Sq W & Broadway $ 50 1,200 $ 5,000
Park Ave S & East 18th Street $ 50 1,700 $ 7,118
Union Sq W & East 14th Street $ 44 2,300 $ 8,409
Park Ave S & East 17th Street $ 58 1,800 $ 8,662
E 23rd St & Third Avenue $ 42 2,400 $ 8,400
Fifth Ave & East 29th Street $ 46 1,800 $ 6,975
Fifth Ave & East 12th Street $ 55 1,300 $ 5,958
E 28th St & Madison Avenue $ 46 2,200 $ 8,433
Broadway & East 20th Street $ 76 2,000 $ 12,666
Park Ave S & East 26th Street $ 65 2,100 $ 11,375
E 21st St & Broadway $ 35 1,500 $ 4,375
Address $ / SF SF Monthly Rent
Park Ave S & East 18th Street $ 50 4,100 $ 17,168
Madison Ave & East 29th Avenue $ 36 2,700 $ 8,015
E 23rd St & Park Avenue $ 33 6,100 $ 16,775
Fifth Ave & East 19th Street $ 48 3,300 $ 13,303
Madison Ave & East 26th Street $ 42 7,700 $ 26,709
Address $ / SF SF Monthly Rent
Union Sq W & Broadway $ 38 11,000 $ 35,062
Park Ave S & East 18th Street $ 50 10,900 $ 45,643
E 23rd St & Park Avenue $ 45 18,400 $ 69,000
Fifth Ave & East 19th Street $ 48 19,500 $ 78,609
Broadway & East 20th Street $ 69 18,200 $ 104,650
Address $ / SF SF Monthly Rent
E 28th St & Park Avenue South $ 35 2,300 $ 6,708
E 23rd St & Broadway $ 35 2,300 $ 6,785
E 16th St & Union Square East $ 58 1,600 $ 7,733
E 21st St & Between Park Avenue S $ 45 1,000 $ 3,779
First Ave & East 13th Street $ 31 1,700 $ 4,335
Fourth Ave & Between East 12th Street $ 55 1,100 $ 4,999
E 28th St & Between Lexington Avenue $ 34 1,400 $ 3,994
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 120 2,500 $ 25,000
E 19th St & Broadway $ 52 5,500 $ 24,062
E 18th St & Broadway $ 31 7,500 $ 19,500
Broadway & East 21st Street $ 58 4,100 $ 19,816
5th Ave & East 29th Street $ 41 3,300 $ 11,167
E 24th St & Park Avenue South $ 48 5,200 $ 20,800
Park Ave S & East 24th Street $ 42 4,000 $ 14,000
Fifth Ave & East 17th Street $ 59 2,800 $ 13,832
Address $ / SF SF Monthly Rent
Broadway & East 18th Street $ 67 11,200 $ 62,439

Rent Nearby Coworking Office

Type of Space Class A Class B Class C
Windowed office/person $ 2,000/mo $ 1,250/mo $ 1,000/mo
Interior office/person $ 1,250/mo $ 750/mo $ 500/mo

Retail Spaces for Rent

Nearby retail Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
First Ave & East 22nd Street $ 162 2,200 $ 29,749
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
W 145th St & Between Broadway $ 77 4,500 $ 29,043
Fifth Ave & East 21st Street $ 61 5,500 $ 28,141
Fifth Ave & East 20th Street $ 97 2,500 $ 20,291
Fifth Ave & East 16th Street $ 54 9,700 $ 43,973
E 23rd St & Lexington Avenue $ 125 11,600 $ 120,833
Address $ / SF SF Monthly Rent
E 16th St & 3rd Avenue $ 90 800 $ 6,023
Address $ / SF SF Monthly Rent
E 23rd St & Broadway $ 180 1,500 $ 22,500
Address $ / SF SF Monthly Rent
Broadway & East 17th Street $ 107 3,000 $ 26,862
Third Ave & East 27th Street $ 125 2,900 $ 30,305
E 16th St & Fifth Avenue $ 32 2,800 $ 7,571
E 26th St & Between 5th Avenue $ 49 2,200 $ 8,948
E 16th St & Between Union Square W $ 126 2,000 $ 21,008
E 23rd St & Park Avenue $ 115 2,500 $ 23,958
E 17th St & Between Broadway $ 55 2,800 $ 12,833
E 19th St & Broadway $ 48 5,500 $ 22,000

Rent Medical Space

Nearby medical Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
3rd Ave & Union Street $ 58 1,100 $ 5,362
Address $ / SF SF Monthly Rent
Union Sq E & East 15th Street $ 46 3,100 $ 11,883
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 50 6,100 $ 25,416
W 145th St & Between Broadway $ 35 9,500 $ 27,708
Address $ / SF SF Monthly Rent
E 16th St & Third Avenue $ 52 1,400 $ 6,043
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
345 Park Avenue South nyc
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Lease 345 Park Avenue South

Rent 345 Park Avenue South Property Overview

Bulding Address: 345 Park Avenue South
Building Name: The Iselin Bldg
Building Alternate address: 345 Park Ave South
Zip Code:10010
Neighborhood:Gramercy Park
Borough:Manhattan
Stories:12
Year Built:1912
Building Class:A


345 Park Avenue South is located in Manhattan, NYC, and has a rich history. Originally completed in 1912, the building was designed by architect William H. Whittal and was previously known as the Armory Building. In 2021, Deerfield invested in a comprehensive renovation, transforming it into the CURE. life sciences hub. This modernization aimed to create a state-of-the-art facility for life sciences, digital health, and tech-enabled companies.

The building features 12 floors with 300,000 square feet of Class A space, including lab-ready areas and amenities such as a rooftop terrace, fitness center, lounge club, and conference facilities. It is situated in the heart of Silicon Alley, providing easy access to various transportation options and nearby amenities.

Today, 345 Park Avenue South hosts Deerfield's headquarters alongside other tenants like ProTara Therapeutics and Helaina, creating a vibrant ecosystem for innovation in healthcare and technology.

345 Park Avenue South, located in Manhattan, NYC, is a premier life science hub. This building offers state-of-the-art facilities, including lab spaces and flexible office areas, designed to foster collaboration among leaders in technology, life sciences, and digital health.

The 12-story structure, originally completed in 1912 and renovated in 2021, features 300,000 square feet of Class A office space. It is situated in the heart of Silicon Alley, near Madison Square Park, offering easy access to various public transportation options.

Amenities include a rooftop terrace with event spaces, a lounge club, fitness center, and wine cellar. The location is ideal for businesses in the life sciences and healthcare sectors, providing both wet and dry lab capabilities.

Cure, the life science ecosystem housed here, includes event spaces and support services like in-house AV and catering.

This site is also known for its vibrant neighborhood, which includes top restaurants, bars, and shops, making it a prime location for innovation and collaboration.


345 Park Avenue South in Manhattan offers a range of amenities, including:

  • Rooftop Terrace with flexible event space and stunning views of Manhattan.
  • Lounge Club and kitchen.
  • Fitness Center (available at an additional cost).
  • NaCl Café on the 12th floor.
  • State-of-the-art Conference Center with multiple meeting and event venues.
  • Exclusive Wine Cellar.
  • Fully Furnished Workspaces and Laboratory-Ready Spaces for life sciences and digital health applications.

345 Park Avenue South, located in the heart of Manhattan's Midtown South, is a pivotal office space for several prominent tenants. The building, once known as the Armory Building, underwent a significant renovation to become a state-of-the-art life sciences hub.

Notable Tenants Include:

  • Deerfield - A leading investment firm in life sciences.
  • ProTara Therapeutics - A biotechnology company focused on innovative therapies.
  • Helaina - A company operating in the life sciences sector.
  • Bank of America Financial Center - Offering financial services.
  • Test Now and Go - Providing rapid testing solutions.
  • The Upland restaurant - Situated on the ground floor.

Internet providers available at 345 Park Avenue South in Manhattan:

  • Verizon: Offers Fios with high speeds up to 2 Gbps, although availability might vary in the area.
  • Spectrum: Provides cable services with speeds up to 1 Gbps, widely available in Manhattan.
  • Astound Broadband Powered by RCN: Delivers high-speed fiber internet with speeds up to 1.5 Gbps, though coverage may be spotty in some areas.

345 Park Avenue South in Manhattan is conveniently located near various public transportation options. The nearest subway stations include:

- 28th Street (4-minute walk)

- 23rd Street (2-minute walk)

- 33rd Street (8-minute walk)

Cross streets:

- Park Avenue South & Lexington Avenue

- Nearby bus stops and additional transportation details are available through local transit services.

Rent Office - 345 Park Avenue South Average

Year $ / SF
2018 62.0
2019 62.0
Year$ / SF

Lempert Brothers Intl USA. Testimonial

Lempert Brothers Intl USA. testimonial To Whom It May Concern: We had the pleasure of working with Stephen Sunderland months ago when we were in search of new office space for our growing company. He was of great assistance with all the questions we had about today's real estate market. HisRead more

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